ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE

ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE - Names and Identifiers

Name	Isoquinoline-5-sulfonyl chloride
Synonyms	Isoquinoline Impurity 6 5-Isoquinolinesulfonyl chloride 5-isoquinolinesulfonyl chloride ISOQUINOLINE-5-SULFONYL CHLORIDE Isoquinoline-5-sulfonyl chloride Isoquinoline-5-sulfonylchlorideHCl isoquinolin-5-ylsulphonyl chloride 5-Isoquinolinesulfonylchloride(9CI) ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE Isoquinoline-5-sulfonyl chloride reference substance
CAS	84468-15-5
InChI	InChI=1/C9H6ClNO2S/c10-14(12,13)9-3-1-2-7-6-11-5-4-8(7)9/h1-6H

ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE - Physico-chemical Properties

Molecular Formula	C9H6ClNO2S
Molar Mass	227.67
Density	1.483
Melting Point	173-183°C
Boling Point	371.2±17.0 °C(Predicted)
Flash Point	178.3℃
Solubility	DMSO (Sparingly, Heated)
Vapor Presure	2.23E-05mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	3.09±0.13(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Stability	Moisture Sensitive
Refractive Index	1.646

ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
HS Code	29334900

ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE - Reference Information

overview

isoquinolin-5-sulfonyl chloride is a colorless liquid and is an important intermediate for the synthesis of fasudil hydrochloride. Fasudil hydrochloride is an inhibitor of RHO kinase. By increasing the activity of myosin light chain phosphatase, it dilates blood vessels, reduces the tension of endothelial cells, improves microcirculation of brain tissue, and can antagonize anti-inflammatory factors, protect nerve against apoptosis, and promote nerve regeneration.

Last Update：2024-04-09 15:16:38